Abstract
The effects of cytoplasmic acidification by nigericin, monovalent cation ionophore, on platelet activation induced by arachidonic acid (AA) were examined. AA-induced aggregation and TXB 2 formation were inhibited with decreasing cytoplasmic pH (pHc). Although TXA 2 receptor agonists (STA 2, U-46619)-induced aggregation of some platelet samples were suppressed by nigericin, the suppression did not correspond to the acidification of pHc. Aggregation initiated by collagen was inhibited by nigericin. The inhibition, however, was not observed in platelets treated by aspirin. These results suggest that the inhibition of AA-induced aggregation by cytoplasmic acidification is due to inhibition of the metabolism of AA to TXA 2.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
