Abstract
The effect of cyclosporin A on the adherence of Escherichia coli strains to human umbilical vein endothelial cells was studied. Compared with the controls, bacterial adherence significantly increased following preincubation of the cells with cyclosporin A at 50 mg/l and more significantly, to cells preincubated with cyclosporin A at 100–200 mg/l. The results showed that cyclosporin A use may be accompanied by an increased bacterial adherence to host cells in vivo. This effect was achieved using a wide range of therapeutic doses.
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