Abstract
AbstractThe effect of cyclophosphamide on the transplantability of hamster tumor cells transformed by PARA‐adenovirus 7 was investigated. Normally, such syngeneic transplants seldom, if ever, regress spontaneously. It was found that chemotherapy was remarkably effective against this neoplasm. A single inoculation of the drug (200 mg/kg) prevented the growth of 104‐105 transplanted cells, and promoted regression of palpable tumors. Weekly drug inoculations prolonged the survival of hosts bearing large neoplasms. Animals successfully treated proved to be resistant to subsequent tumor‐cell challenge. The chemical did not prevent tumor growth if given prior to the transplant. There is suggestive evidence that host tumor resistance may have contributed to the success of cyclophosphamide therapy.
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