Abstract
Diabetic nephropathy (DN) is a severe microvascular complication that occurs in diabetes patients. In this study, we investigated the effect of cyclophosphamide (CTX) on expression of matrix metalloproteinases (MMP-9) and transforming growth factor-β1 (TGF-β1) in renal tissue of rats with DN. We found CTX significantly reduces KI and blood glucose levels, microalbuminuria, and blood urea nitrogen. It also decreases the expression of TGF-β1 and increases the expression of MMP-9. Our data suggest CTX may reduce the excretion of urine proteins, alleviate kidney hypertrophy, and reduce blood glucose level through regulation of TGF-β1 and MMP-9 gene expression.
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