Abstract
Spontaneously hypertensive rats were found to have a greater density of specific [ 3H]spiroperidol binding sites in the corpus striatum and hypothalamus when compared to the normotensive Wistar-Kyoto rats. The apparent dissociation constant (K d) for [ 3H]spiroperidol binding in the two groups of rats did not differ. Chronic administration of cyclo(leucyl-glycine), an analog derived from the hypothalamic peptide, melanotropin release inhibiting factor, decreased the enhanced number of [ 3H]spiroperidol binding sites in the triatum and hypothalamus of the hypertensive rats. These results further suggest that cyclo(leucyl-glycine) interacts with brain dopamine receptors, and that brain dopamine receptors may be involved in the etiology of hypertension.
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