Effect of cycloheximide on the initiation and maintenance of increased seizure readiness in the rat sensorimotor cortex

Abstract

Cycloheximide does not affect the thresholds of elicitation of either direct or transcallosal responses of the sensorimotor cortex, the poststimulation elevation of brain excitability immediately after termination of the 20th series of rhythmic electrostimulations, or the diminishment of its excitability 24 h later. Cycloheximide administration does not change the latency or the duration of the first seizure discharge but does abolish the potentiation of the duration of the seizure discharges. When tested again a day later, control rats exhibit a marked decrease of the latency of the first seizure discharge and an increase of discharge amplitude as compared to the corresponding parameters in the first series of rhythmic electrostimulations.