Effect of Cycloheptenylethyl Barbituric Acid, "Medomin," on Intestinal and Uterine Smooth Muscle.

Abstract

Summary1. Cycloheptenylethyl barbituric acid produces relaxation of the excised segments of intestine and uterus of cats and rabbits. 2. The intact intestine of dogs and the intact uterus of rabbits and dogs respond to the drug by a decrease in the tonus and a lessening of the rhythmic contractions. In the cats, however, increased tonus of the uterus was observed on some occasions. 3. In only 3 out of 79 injections of ultra-short, short and intermediate acting barbiturates was there a suggestion of an increase in the general tonus of the intact gut following the primary depression. About 50% of our experiments had to be discontinued during the period of intestinal relaxation because of the excitement produced in the animal as it was recovering from the barbiturate hypnosis.