Abstract
The xanthine-derivatives theophylline (TPH), caffeine (CAF) theobromine (TBR) and 1-methyl-3-isobutyl-xanthine (MIX) are well-known inhibitors of cyclic nucleotide phosphodiesterase (PDE), and many of their in vivo effects have been attributed to impairment of cyclic AMP hydrolysis (e.g. bronchodilation, diuretic action, effect on heart). It was observed, however, that these drugs are also potent stimulators of prostaglandin synthetase (PGS) from bovine seminal vesicle microsomes (BSVM) in vitro. Papaverine (PAP), a PDE-inhibitor chemically unrelated to xanthine, had no effect on PGS. It was also found that BSVM have high PDE-activity, and dose-response curves were established with the xanthines and PAP in regard to BSVM-PDE inhibition and BSVM-PGS stimulation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
