Effect of Cyanide on the Liver Histological and Biochemical Status

Abstract

The biochemical and histological response of the rats following dosed on the potassium cyanide wasexamined in this study, about 36 rats were randomly divided into sex groups ; G0 which considers the controlgroup, G1 oral dosed with potassium cyanide concentration 500ppm (500U/L), G2 dosed with concentration1000ppm (1g/L), waiting for a long time 21 days before anatomy the animal. G3, G4, and G5 dosed with2000ppm, 2500ppm, and 3000ppm, respectively to study the effect of high dose concentration on the liverhistology, liver enzyme and lipid profile and determined LD50 (lethal dose), and LC50 (lethal concentration).After anatomy, the animal experiment to study the liver histological and determine the effect of potassiumcyanide concentration on the liver enzymes such as HDL, triglyceride, and cholesterol, compared the resultwith the control group and previous studies . The study indicated the presence of a significant increase (P?0.05) in ALP in the G1 , a non-significant increase (P? 0.05) in the G2 , the G3 and G4 groups suffered froma significant increase (P? 0.05) while the G5 group suffered from a non-significant decrease (P? 0.05) incomparison with G0. The present study also showed that there was a significant increase (P ? 0.05) in GPT inthe G1 , G2 , G3 , G4 in comparison with G0. The study also indicated the presence of a significant increase(P ? 0.05) in GOT In the G1 , G2 and G3 compared to the G0.