Abstract
Although ubiquinone in electron transport particles (ETP) is reduced by succinate at the same rate in the presence of both cyanide and Antimycin A, it is reoxidized upon addition of malonate more rapidly and completely in the presence of Antimycin A. With cytochrome b in these particles, the inhibitors play reversed roles. The cytochrome is rapidly and completely reduced in particles treated with Antimycin A; reoxidation is incomplete on addition of malonate. With cyanide, reduction of cytochrome b by succinate is slow and incomplete; reoxidation is complete on addition of malonate. This behavior is strong evidence for a branched pathway of electron transport in these particles. NADH reduces more cytochrome b than does succinate, but Antimycin A is still needed for complete reduction. Succinate reduced only half the flavoprotein in ETP which can be reduced by NADH in the presence of either cyanide or Antimycin A.
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