Effect Of Curcumin And Honey To Pharmacokinetics Of Paracetamol In Male Wistar Rats

Abstract

Honey and curcumin is widely consumed by children as food supplements. Honey is useful as an antioxidant and antibacterial, while curcumin is useful as an antioxidant, antiinflammatory, antibacterial, antiviral. Both health supplements are not infrequently used in conjunction with drugs, especially paracetamol. This study aims to determine the effect of curcumin and honey on the pharmacokinetic parameters of paracetamol in male rats. In this study, test animals were divided into 3 groups: control, treatment I and treatment II. In the control group mice were given paracetamol 150mg / KgBW, treatment group I rats were given curcumin 18 mg / KgBW, 1 hour and then given paracetamol 150mg / KgBW whereas the treatment group II rats given a dose of honey 7.65 mL / KgBW along with giving paracetamol 150mg KgBB . The results showed that administration of curcumin on the pharmacokinetics of paracetamol in mice can decrease the primary parameters of the elimination phase of CLT for 68.25%, increasing the secondary parameter t 1 / 2 at 193.72%, thus increasing the derivative parameters AUC0-inf for 88.36%, and MRT of 155.17% (p absorption process of paracetamol in male rats. Keyewords: Curcumin, honey, paracetamol, pharmacokinetic parameter