Abstract
Objective: To analyze the effect of Argon-Helium cryosurgery (AHCS) on the differentiation of regulatory CD4+ CD25+ T cell (Treg) and its implication in patients with prostate carcinoma. Methods: Peripheral venous blood samples were obtained from 40 patients with prostate cancer before AHCS and at 3 months and 6 months after AHCS. PSA in the peripheral blood was measured by radioimmunotherapy. The percentage of Treg cells and T lymphocyte subsets (CD3+ T, CD4+ T, CD8+ T, CD4+ T/CD8+ T, and NK cells) in the peripheral blood was measured by flow cytometry. Results: After AHCS, PSA level in the peripheral blood was decreased significantly (P0.01). After AHCS, the percentages of Treg cells were decreased (P 0.01). At 3 months and 6 months after AHCS, the percentages of Treg cells were steady (P0.05), the percentages of CD3+ T, CD4+ T, NK and CD4+ T/CD8+ T were significantly increased after AHCS (P0.01), and the percentage of CD8+ T cells was significantly decreased after AHCS (P0.01). Correlation analysis showed that the decrease of PSA was positively correlated with the decrease of the percentage of Treg cells (r=0.76, P0.01). Conclusion: After AHCS, the abnormal distribution of subsets of T-lymphocytes can be improved. The percentage of Treg cells is correlated with tumor load.
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