Abstract
In this study we report a significant inhibition of delayed-type hypersensitivity (DTH) reactions in mice pretreated for 5 days with different doses of a crude or a purified preparation of human chorionic gonadotropin (HCG). Purified HCG was found to be more potent than crude HCG in its immunosuppressive capacity, while the HCG subunits and desialylated HCG were without immunosuppressive effect. The inhibition of the DTH reaction was completely reversed by the simultaneous injection of indomethacin or aspirin, two known inhibitors of prostaglandin synthesis. Our findings indicate that HCG itself can suppress the DTH response and that the mechanism involves the release of prostaglandins.
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