Abstract
The objective of this study was to formulate an oral sustained release delivery system of sodium diclofenac(DS) based on sodium alginate (SA) as a hydrophilic carrier in combination with chitosan (CH) and sodium carboxymethyl cellulose (SCMC) as drug release modifiers to overcome the drug-related adverse effects and to improve bioavailability. Microspheres of DS were prepared using an easy method of ionotropic gelation. The prepared beads were evaluated for mean particle size, entrapment efficiency, swelling capacity, erosion and in-vitro drug release. They were also subjected to various studies such as Fourier Transform Infra-Red Spectroscopy (FTIR) for drug polymer compatibility, Scanning Electron Microscopy for surface morphology, X-ray Powder Diffraction Analysis (XRD) and Differential Scanning Calorimetric Analysis (DSC) to determine the physical state of the drug in the beads. The addition of SCMC during the preparation of polymeric beads resulted in lower drug loading and prolonged release of the DS. The release profile of batches F5 and F6 showed a maximum drug release of 96.97 ± 0.356% after 8 h, in which drug polymer ratio was decreased. The microspheres of sodium diclofenac with the polymers were formulated successfully. Analysis of the release profiles showed that the data corresponds to the diffusion-controlled mechanism as suggested by Higuchi.
Highlights
Oral drug delivery using biodegradable natural polymeric particulate systems are becoming a clinical reality with many benefits for patients
This study showed that drug-loading and release characteristics of diclofenaco sódico (DS)-loaded alginate beads, alginatechitosan beads, and alginate-chitosan-Sodium CMC (SCMC) beads are dependent on the presence of a polyelectrolyte complex between alginate and chitosan; calcium chloride concentration in the gelation medium, drug to polymer ratio, and pH of the dissolution medium
Differential Scanning Calorimetric Analysis (DSC) and X-ray Powder Diffraction Analysis (XRD) studies qualitatively confirmed the physical state of the drug sodium diclofenacin the beads
Summary
Oral drug delivery using biodegradable natural polymeric particulate systems are becoming a clinical reality with many benefits for patients. Alginate is a naturally occurring polysaccharide obtained from marine brown algae It is composed of linear copolymers of 1, 4-linked β-D mannuronic acid and α-L glucuronic acid. Examples of PEC for controlling drug release include alginate/chitosan (Parfitt, Marindale, 1996), chitosan-cellulose multicore microparticles (Sanil et al.,2007), chitosan-coated pectin (Sipahigil et al, 2006), chitosan/poly(acrylic acid) complexes (Sezer, Akbuga, 1999), poly(vinylalcohol)/sodium alginate blend beads (Gonzålez-Rodriguez et al, 2002), and poly(methacrylic acid-g- ethylene glycol) particles (Lee et al, 1996). The non-steroidal anti-inflammatory drug, sodium diclofenac is a good candidate for the development of oral sustained release formulations. It is administered as conventional tablets/capsules for the treatment of rheumatoid arthritis, osteoarthritis with a dose of 75-150mg divided for administration 2-3 times a day (Parfitt et al, 1996). This leads to fluctuation in the drug-blood levels and dose-related adverse effects, and multiple dosing fails to release the drug in the desired amount at the desired rate which often results in poor patient compliance and inefficient therapy (Peter et al, 1997)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
