Abstract

Antifungal activity of 3-methylcarbazoles from Streptomyces sp. LJK109; an endophyte in Alpinia galangalThongchai Taechowisan, Srisakul Chanaphat, Wanwikar Ruensamran, Waya S. Phutdhawong

Highlights

  • Actinomycetes are the economically valuable bacteria which are ubiquitous in nature with the ability to produce novel secondary metabolites including antibiotics (Berdy, 2012)

  • Effect of culture conditions and critical medium components on antitubercular pigment production from novel Streptomyces sp D25 isolated from Thar desert, Rajasthan was investigated

  • The present study reports the effect of culture conditions and critical medium components on antitubercular pigment production from novel Streptomyces sp D25 isolated from Thar desert, Rajasthan

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Summary

INTRODUCTION

Actinomycetes are the economically valuable bacteria which are ubiquitous in nature with the ability to produce novel secondary metabolites including antibiotics (Berdy, 2012). Since the discovery of streptomycin, the first antibiotic used for anti-TB therapy obtained from Streptomyces griseus, during 1944, numerous anti-TB antibiotics have been reported from various actinobacterial genera Promising candidates such as rifamycin, erythromycin, pacidamycin, caprazamycin, capuramycin and thiolactomycin in clinical trials against MDR-TB are of actinomycete origin (Souza, 2009). Inspired by this excellent track record, a significant effort was made that resulted in the successful isolation of actinobacteria from terrestrial sources for anti-TB screening programs in the past 50 years. The present study reports the effect of culture conditions and critical medium components on antitubercular pigment production from novel Streptomyces sp D25 isolated from Thar desert, Rajasthan

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