Abstract
To analyze the effect of intra-oral application of CPP-ACP and CPP-ACPF pastes on the surface hardness of initial dental erosion lesions.Bovine enamel specimens were randomly assigned into 6 volunteers in 3 treatment groups: GI: CPP-ACP paste, GII: CPP-ACPF paste and GIII (Control): Placebo paste without CPP-ACP and without fluoride. Enamel specimens were selected by surface hardness (SHi), in vitro eroded by immersion in hydrochloric acid for 30 seconds (SHdes) and randomized between treatment groups and volunteers, who used the palatal intraoral device for 2 hours, applied the treatment on the specimens and used the palatal intraoral device for an additional 3 hours in 3 crossed phases, interspersed with a 7-day washout period. Subsequently, the surface hardness (SHre) was measured to estimate the re-hardening potential of the softened enamel promoted by treatments. Data were analyzed using the t-test and one-way ANOVA, adopting 5% significance level. Mean final and post-erosion hardness values were statistically significant for pastes tested (p<0.05), which presented re-hardening effect of the softened enamel, but with no difference between them and placebo (p>0.05). CPP-ACP and CPP-ACPF pastes did not demonstrate higher efficacy in re-hardening the eroded enamel compared to placebo paste.
Highlights
To analyze the effect of intra-oral application of casein phosphopeptideamorphous calcium phosphate (CPP-ACP) and CPP-ACPF pastes on the surface hardness of initial dental erosion lesions
The use of casein phosphopeptideamorphous calcium phosphate (CPP-ACP) is among the strategies to control tooth erosion, a milk protein substance consisting of casein
Considering the importance of the subject and the scarce literature currently available on the efficacy of CPP-ACP pastes on mineral precipitation of initial erosive lesions, and knowing that in situ studies better mimic the clinical reality to obtain scientific information[21], the aim of this study was to analyze the in situ effect of a single intrabuccal application of CPP-ACP and CPP-ACPF pastes on the surface hardness of initial erosion lesions in bovine enamel
Summary
To analyze the effect of intra-oral application of CPP-ACP and CPP-ACPF pastes on the surface hardness of initial dental erosion lesions. When in contact with the dental surface, acids cause the dissolution of the inorganic hard tissue[7,8,9], causing decreased mechanical resistance and reduced hardness of the surface layer[10] In this way, dental erosion can be divided into two phases: Phase 1: Erosion (chemical process), with partial demineralization of the enamel or dentin, causing surface softening; Phase 2: Erosive tooth wear, which characterizes the advanced phase, where there is loss of the previously softened surface through the combined effect of erosion and mechanical wear of the tooth surface[11,12,13]. CPP-ACP acts as a supplemental source of calcium and phosphate bioavailable in the oral environment, being proposed both for inhibiting loss of minerals[1] and for intensifying their deposition on demineralized lesions of the dental enamel, such as erosive lesions[16]
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