Abstract
This manuscript studies the effect of counterion on the phase behaviour during lyophilization of indomethacin salts. Salt forms of indomethacin namely, sodium, potassium, rubidium and cesium were prepared in situ and analyzed by modulated differential scanning calorimetry (MDSC) for determination of the critical process parameter for lyophilization. At a cooling rate of 17 °C/min, indomethacin salts separated as amorphous form on freeze concentration. T g ′ of indomethacin salts followed the order: sodium (−35.36 °C) > potassium (−38.90 °C) > rubidium (−43.70 °C) > cesium (−47.84 °C) salt. T g ′ was followed by crystallization exotherm during the heating run for all salts, except indomethacin cesium. At slower cooling rates (0.5 and 1 °C/min), indomethacin sodium, potassium and rubidium crystallized in the cooling run, while indomethacin cesium remained amorphous. The differential crystallization behaviour of indomethacin salts was explained in terms of bulkiness of the counterion, molecular interactions and structural relaxation behaviour near T g ′ . The research work has implications in lyophilization processing as well as the stability and performance of final product.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
