Year-end Sale % OFF 
Abstract
ABSTRACT The growth of the ventral and the dorsolateral prostate, the coagulating glands and the seminal vesicles was studied in cortisone-treated and non-treated castrated non-adrenalectomized and castrated adrenalectomized rats. The cortisone was administered in daily doses of 3 mg or 9 mg for a period of 15 days. Combined castration and adrenalectomy resulted in a greater degree of atrophy of the ventral prostate than castration alone, thus indicating some maintenance effect of the adrenals on the ventral prostate. No differences in the other accessory reproductive organs were demonstrated when comparing non-treated castrated non-adrenalectomized with castrated adrenalectomized rats. Both doses of cortisone stimulated the growth of the dorsolateral prostate, the coagulating glands and the seminal vesicles, but the larger dose resulted in a greater degree of stimulation. Only the larger dose of cortisone gave histological changes in the ventral prostate indicative of a slight stimulating effect. Catabolic or anti-anabolic effects of cortisone as registered by a decrease in body weight and weight of the levator ani muscle did not inhibit the growth stimulating effect of cortisone on the accessory reproductive organs. Cortisone stimulated the growth of both the epithelium and the smooth muscle tissue of the glands. The effect on the different accessory reproductive organs after cortisone administration was contrary to previous studies, which demonstrated the stimulating effects of androgens in the rat, in that the ventral prostate was relatively unstimulated. Possible mechanisms for the stimulation of the growth of the accessory reproductive organs are discussed in the light of our present knowledge of cortisone metabolism and of the secretion in the cortisone-treated rats of hormones which have been found to modify the growth of the accessory reproductive organs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
