Abstract
Summary and ConclusionsLivers of rabbits that received 25 mg of cortisone for 1, 2, 3, and 6 days were studied chemically and histologically. Under this stimulus, nitrogen content decreased and carbohydrate content increased in the livers. The PNA and DNA per g of liver both decreased but the ratio of PNA/DNA rose steadily with increasing number of days of cortisone administration. Analysis of livers of 2 animals killed 9 days after cessation of cortisone injection indicated repletion of DNA, PNA, and nitrogen. The nucleic acid composition of the kidneys was not altered by cortisone. A number of alternate explanations for the observations are advanced.
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