Abstract
Corticotropin (40 I.U./kg body weight) was injected i.p. to intact and adrenalectomized rats. One hour after injection, the rats were sacrificed and their ascorbic acid, dehydroascorbic acid, and diketogulonic acid levels were determined in liver, while only the total ascorbic acid was determined in blood. Activities of ascorbic acid synthesizing enzymes, d-glucurono-δ-lactone hydrolase, l-gulono-γ-lactone hydrolase, TPN- l-hexonate dehydrogenase and l-gulono-γ-lactone oxidase were estimated in liver. The activities of ascorbic acid degrading enzymes, dehydroascorbatase and 2,3 diketoaldonate decarboxylase were studied in liver and kidney. In corticotropin-administered normal rats there was slight increase in ascorbic acid and dehydroascorbic acid contents of liver as compared to control (normal rats). There was a decrease in the diketogulonic acid content of liver. Corticotropin had no appreciable effect on the activities of any of the ascorbic acid synthesizing enzymes in normal rats. Under similar conditions, there was an appreciable decrease in the activities of dehydroascorbatase and 2,3 diketoaldonate decarboxylase both in liver and kidney. It has been suggested that corticotropin does not work directly but indirectly through the adrenocortical axis since it had no effect in adrenalectomized rats.
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