Abstract

Studies of the enzymatic make-up in established lines of mammalian cells have revealed remarkable similarity among cells of diverse origins (1). Alkaline phosphatase was found to constitute an exception since it varied in activity not only from one strain to another but also within the same strain of cells, depending upon the clone being studied (2,3). Although little is known about the factors controlling the levels of this enzyme in cell cultures, a recent study of Cox and MacLeod (3) has shown that prednisolone increased the level of alkaline phosphatase in HeLa cells. The work reported in this communication primarily involved a study of the relationship between the steroid structure and its ability to stimulate alkaline phosphatase.

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