Effect of cortical masticatory area stimulation on swallowing in anesthetized rabbits

Abstract

The effects of stimulation of the cortical masticatory area (CMA) on swallowing evoked by superior laryngeal nerve (SLN) were studied in anesthetized rabbits. Electromyographic activity of the thyrohyoid, masseter, and digastric muscles and jaw-movement trajectories were recorded to monitor rhythmic jaw movements (RJMs) or swallowing. A systematic series of microelectrode penetrations within the CMA was made for each animal, and the effects of CMA stimulation on swallowing were tested by comparing the number of swallows evoked by stimulation of the CMA alone, the SLN alone, and simultaneous stimulation of the SLN and CMA. A significant facilitatory effect was observed in 49 (52%) of the 95 CMA loci tested. No significant effect was noted in the remaining 46 loci. Three different types of RJMs were evoked by CMA stimulation, and topographical organization was noted among CMA loci that evoked different types of RJMs. A high percentage of (77%) the CMA loci that evoked RJMs with a prominent horizontal excursion of the jaw facilitated swallowing and was located in the posterolateral and deep part of the CMA. A majority (88%) of the CMA loci that evoked RJMs with small circular jaw movements did not affect swallowing and was located in the anteromedial and shallow part of the CMA. The facilitatory effect of CMA stimulation on swallowing remained even after removal of peripheral sensory inputs by means of deafferentation of infraorbital and inferior alveolar nerves. Results suggest the existence of facilitatory descending pathways to the swallowing center from particular intracortical loci of CMA.