Abstract
Radiation sensitization of uracil (Ura) by CuII ions has been investigated using cobalt-60 γ-rays. In N2O-saturated solution, when no additive is present, the base degradation yield, G(– Ura), is only ca. 3.3, but when CuII ions are added in either a free or complexed state to the solution before irradiation, G(– Ura) is found to increase to ca. 5.1. The enhanced degradation of the base is derived from the oxidized transient, e.g. UraOH+, although reduction of CuII to CuI has been ascribed to all the primary adducts, e.g. UraH, UraOH and Ura–. Glycol and isobarbituric acid constitute the major products of radiolysis, which are derived from the oxidized UraOH+ species. Hydroxydihydrouracil and its dimer have also been detected in significant yields when the radiolysis is carried out at comparatively high absorbed doses. The formation of these products has been ascribed to a secondary reaction between UraOH and CuI which proceeds through the intermediate formation of a Cu—C bond.
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Schedule a callMore From: Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases
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