Abstract
ABSTRACT Background: Hypovolemic shock is a common disease in polytrauma patients and may develop ischemia in various organs, increasing morbidity and mortality. The bowel is usually most affected by this condition. Aim: To evaluate the effects of copaiba oil on the intestinal mucosa’s injury of rats submitted to hypovolemic shock. Method: Fifteen rats were divided into three groups: sham - simulated surgery; ischemia - animals submitted to hypovolemic shock; and copaiba - animals submitted to hypovolemic shock previously treated with copaiba oil. Mean blood pressure, arterial blood gas after shock induction, degree of intestinal lesion and villus length were evaluated. Results: The sham presented the lowest values of lactate and PaCO2 and the highest values of mean arterial pressure, pH and bicarbonate in relation to the other groups. The degree of mesenteric lesion was zero in the sham group; 3.00±1.00 in the ischemia group; and 3.00±0.71 in the copaiba group. The villus length was 173.60±8.42 in the sham, 142.77±8.33 in the ischemia and 143.01±9.57 in the copaiba group. There was a significant difference between the sham and the other groups (p<0.05); however, there not significant difference between groups Ischemia and copaiba. Conclusion: Administration of copaiba oil did not reduce the intestinal mucosa lesion of rats after hypovolemic shock.
Highlights
Trauma is one of the leading causes of death in the world, especially in young adults[12]
This study aims to evaluated the effects of copaiba oil on the intestinal mucosa of rats submitted to hypovolemic shock
The animals were randomly assigned into three study groups (n=5): 1) sham group (SG): same surgical procedure as in remaining groups was performed, but no hypovolemic shock was induced; 2) ischemic group (CG): animals submitted to hypovolemic shock; 3) copaiba group (CG): animals submitted to hypovolemic shock previously treated with copaiba oil
Summary
Trauma is one of the leading causes of death in the world, especially in young adults[12]. Several are the mechanisms that lead to severe organ dysfunctions[16], and hypovolemic shock is one of the most common It causes ischemia of several organs, especially kidneys and splanchnic territory[3,15]. The bowel is sensitive to ischemia because of its high metabolic activity[19]; resulting in worsening of wound healing after anastomoses5.7, increased fistulas tax, and difficulty in adequate nutrients’ absorption, causing malnutrition, anemia and diarrhea. It is one of the main sources of bacteria causing sepsis, which happens with the breakdown of the intestinal barrier allowing wide bacterial translocation[17].
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