Abstract
Poly(ethylene glycol)-block-poly(acrylic acid) (PEG-PAA) is modified by 3-aminophenylboronic acid (APBA) with different modification degrees, such as PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) , PEG(114) -b-(PAA(0.23) -co-PAAPBA(0.77) )(170) and PEG(114) -b-(PAA(0.02) -co-PAAPBA(0.98) )(170) . Micelles self-assembled from these three copolymers possess glucose-responsiveness at varying pH values. Micelles self-assembled from PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) have glucose-responsiveness at the physiological pH (7.4), endowing them with potential applications in the treatment of diabetes. (11) B magic-angle spinning nuclear magnetic resonance ((11) B MAS NMR) analysis indicates that interactions between PAAPBA segments and PAA segments induce boron changes from the trigonal planar form to the tetrahedral form, resulting in glucose-responsiveness of PEG(114) -b-(PAA(0.37) -co-PAAPBA(0.63) )(170) micelles at pH 7.4.
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