Abstract
The effects of radiological contrast media on red cell morphology and rigidity have been studied. It has been shown that all the contrast agents studied, even when iso-osmolar with plasma, produce changes in red cell morphology, revealing the intrinsic chemotoxicity of contrast medium molecules. The changes are greatest with the most strongly protein-bound medium investigated--meglumine ioglycamide. The effects on red cell rigidity, on the other hand, appear purely a function of osmolality, being entirely reproducible with hyperosmolar solutions of saline. At concentrations iso-osmolar with plasma no effect on deformability is observed. Since the increased rigidity of red cells induced by contrast medium adversely affects blood flow, the use of the new low-osmolality contrast media is particularly recommended in pulmonary angiography and renal arteriography.
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