Effect of continuous positive airway pressure on serum soluble lectin-like oxidized low-density lipoprotein receptor-1 level in patients with obstructive sleep apnea syndrome

Abstract

Objective To evaluate serum soluble lectin-like oxidized low density lipoprotein receptor -1 (sLOX-1) level in patients with obstructive sleep apnea syndrome (OSAS) and effect of continuous positive airway pressure (CPAP) on serum sLOX-1 level in patients with OSAS. Methods Twenty cases of moderate and severe OSAS patients were selected as the OSAS group by means of polysomnography (PSG), and 15 healthy cases were enrolled as the control group. The serum sLOX-1 levels were measured in the OSAS group and the control group. After treatment with CPAP in the OSAS group, the serum sLOX-1 level was measured again. Results Before treatment, the serum sLOX-1 level was (105.26±37.47) pg/ml in the OSAS group, in which the serum sLOX-1 level was significantly higher than that in the control group [(99.98±18.78) pg/ml] (P < 0.05). After 1 week CPAP treatment in the OSAS group, the serum sLOX-1 level dropped to (93.34±21.24) pg/ml. Comparing the levels between before and after treatment, the difference was statistically significant (P < 0.05). Before treatment in the OSAS group, the serum sLOX-1 level was positively correlated with apnea hyponea index (AHI) (r = 0.416, P < 0.05). Conclusion The level of serum sLOX-1 increases in patients with OSAS. CPAP can effectively reduce the level of serum sLOX-1 in patients with OSAS. Key words: Obstructive sleep apnea syndrome; Continuous positive airway pressure; Soluble lectin-like oxidized low-density lipoprotein receptor-1