Effect of continuous hemofiltration on patients with acute severe bronchial asthma

Abstract

Objective To investigate the effect of continuous veno-venous hemofiltration (CVVH) on patients with acute severe bronchial asthma.Methods Twenty-six patients with acute severe bronchial asthma who were treated at our intensive care unit from January to December 2011 were enrolled as the control group (male 11,female 12,average age (52 ± 19) years old).The subjects in this group received mechanical ventilation,glucocorticoid,β2 receptor agonist,aminophylline,expectorant,antispasmodic medication and rehydration therapy.Another 38 adults with acute severe bronchial asthina who were treated at our intensive care unit during January 2012 and January 2013 were served as study group (male 17,female 21,average age (57 ± 20) years old),and were assigned to undergo CVVH combined with routine therapy.Mechanical ventilation duration,mean hospital stay,mortality,average survival time and hospitalization expenses were compared between the two groups.Student's t test or Chi-square test were used for data analysis.Results In comparison with the control group,mechanical ventilation duration ((2.8 ± 0.9) vs (5.2±1.8) d),average hospitalization ((5.8± 1.2) vs (12.6± 3.3) d),mortality (7.89％ vs 23.08％),average survival time ((22.9 ± 5.9) vs (13.6 ± 2.2) d) were significantly improved (all P ＜0.05).No difference in cost of hospitalization was found between the two groups (P ＞ 0.05).Conctusion CVVH may be proven to have therapeutic effect on patients with obvious acute severe bronchial asthma. Key words: Acute severe bronchial asthma; Continuous hemofiltration