Effect of conjugated linoleic acid supplementation on quality of life in rectal cancer patients undergoing preoperative Chemoradiotherapy

Elnaz Faramarzi,Sarvin Sanaie,Reza Mahdavi,Mohammad Mohammadzadeh,Behnam Nasirimotlagh

doi:10.12669/pjms.332.11925

Elnaz Faramarzi, Sarvin Sanaie + Show 3 more

Open Access

https://doi.org/10.12669/pjms.332.11925

Copy DOI

Abstract

Objectives:This study set out with the aim of evaluating the effect of conjugated linoleic acid (CLA) supplementation on quality of life in rectal cancer patients undergoing to preoperative chemoradiotherapy.Methods:In this study, 33 volunteer patients with rectal cancer treated with preoperative chemoradiotherapy were allocated in the CLA (n=16) and the placebo groups (n=17). The CLA group and placebo groups received 3 gr CLA/d and 4 placebo capsules for 6 weeks respectively. Before and after intervention, quality of life of patients was assessed by EORTC QLQ-C30.Results:At the end of study, the mean scores of physical function, role function, and cognitive function enhanced significantly in the CLA group while reduced remarkably in the placebo group. Symptom scales improved in the CLA group at the end of study. Comparison of changes in fatigue, pain and diarrhea scores were statistically significant between two study groups (P<0.05). When we compared the global health status scores between two groups, significant changes were observed (P<0.001).Conclusion:It appears that CLA may be helpful in rectal cancer patients by improving global quality of life. Although, other clinical trials with large sample size are needed to achieve more precise results.

Highlights

Colorectal cancer is one of the most common cancers in the world, and it is the third most common cancer in both men and women.[1]
Considering the importance of supportive care in cancer patients and the important role of inflammation in incidence of symptoms which influence quality of life of cancer patients and anti inflammatory effect of conjugated linoleic acid (CLA), we examined the effect of CLA supplementation on quality of life in rectal cancer patients treated with preoperative chemoradiotherapy
Thirty-three volunteer patients with rectal cancer were chosen from the radiotherapy center of Imam Hospital in Tabriz

Summary

Introduction

Colorectal cancer is one of the most common cancers in the world, and it is the third most common cancer in both men and women.[1]. Multiple anti-cancer treatment increase risk of malnutrition in these patients.[2] The suggested mechanism for inducing of malnutrition by radiotherapy in these patients is that exposure to clinically relevant doses of ionizing radiation can active cytokine cascades which stimulate several biological reactions at the cell and tissue levels. It has been reported inflammatory factors (e.g. TNF-a, IL-1b, IL-6, etc) have an important role in metabolic disorders, muscle wasting, and development of symptoms such as anorexia, nausea, fatigue, and pain which affect nutrition status and quality of life of cancer patients.[3]. Foods originated from ruminant animals (such as dairy products and meats) are the rich source of CLA.[10]

Objectives

Methods

Results