Abstract

A study was undertaken to assess the susceptibility of a population of proven reactors to a standard 5g dose of MSG given as part of a lunch‐type snack. The study was also designed to test the response to naturally occurring L‐glutamic acid in amounts comparable with the test dose of MSG. Results show the latency of symptom onset to be consistently longer when MSG is administered in juice accompanied by a snack. Response rate to snacks containing 5g MSG is significantly lower for high protein, high natural L‐glutamic acid and high carbohydrate snacks than for the high‐fat snack or MSG administered without a snack. The high‐fat snack (also low in bulk) afforded no protection.

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