Effect of Concurrent Administration of Choline Salicylate and Acetaminophen on Their Mutual Biotransformation in the Rat

Abstract

Rats were administered either choline salicylate (2 mg./kg.) or acetaminophen (10 mg./kg.) or a combination of both by gastric intubation. Plasma levels of salicylic acid and acetaminophen were measured at various time intervals by suitable modifications of reported analytical methods. Concurrent administration of the two drugs did not alter the plasma salicylic acid levels but resulted in a slight increase of the plasma acetaminophen values at 5 and 10min. Differing degrees of glucuronidation of the two drugs may explain this interaction which, however, appears too low to be of clinical significance.