Abstract
To test theoretical predictions that the membrane rejection coefficient ( R) for rigid macromolecules should decrease with increasing bulk concentration, R was measured at volume fractions of 0.001 and 0.033–0.080 for Ficoll (a crosslinked polysaccharide) and bovine serum albumin (a globular protein) in track-etch polycarbonate membranes having uniform capillary pores. The membranes were characterized by scanning electron microscopy and hydraulic permeability measurements, yielding pore radii of 15–36 nm. R decreased with concentration for all membrane—solute combinations, in fair agreement with a hydrodynamic model of hindered transport in pores. For any given solute and pore size, however, R in either dilute or concentrated solutions was significantly larger than anticipated by the theory. This last finding can be interpreted in terms of a greater effect of macromolecule adsorption on rejection properties than on hydraulic permeability.
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