Abstract
Various non-covalent interactions can be scrutinized by the measurement of physical properties. The nature of interactions between drugs and amino acids governs the functionalization process, so a better understanding demands reliable thermophysical data. Keeping this in mind, we report herein the densities, ρ, ultrasonic speed, u and viscosities, η of glycine, l-alanine, l-valine and l-isoleucine in aqueous-semicarbazide hydrochloride (1 wt% and 2 wt% semicarbazide hydrochloride in water) solvents in the temperature range of 293.15–318.15 K at an interval of 5 K and at atmospheric pressure. The density data have been used to calculate the apparent molar properties like Vϕ, Vϕ° and transfer volume, Vϕ,tr°. From the ultrasonic speed data, thermo-acoustical parameters, such as Ks,ϕ, Ks,ϕ° and transfer compressibility, Ks,ϕ,tr° have been evaluated. The viscosity data have been used to calculate Falkenhagen Coefficient, A, Jones-Dole coefficient, B. The hydration numbers, nH has also been evaluated. The entropies, ΔS°# and enthalpies, ΔH°# activation parameters, Δμ1°# and Δμ2°# were also calculated. The co-sphere overlap model was used to interpret the positive Vϕ,tr° values. In addition, the values of Vϕ°, Ks,ϕ°, B and Δμ2°# have been split into groups’ contributions of the amino acids.
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