Abstract
BackgroundThe aim of this prospective study was to assess the effectiveness of concentrated growth factors (CGF) in preventing the development of alveolar osteitis (AO) after the extraction of partially-erupted mandibular third molars.MethodsSeventy patients (26 men and 44 women) 18 years or older (mean age 25.86; range 18–35) underwent 140 third molar extractions. All the patients presented with bilateral, partially-erupted mandibular third molars and underwent surgical extractions. In each case, one socket received CGF and the other served as a control. The predictor variable was the CGF application and the sides were categorized as ‘CGF’ and ‘non-CGF’. The outcome variable was the development of AO during the first postoperative week. Other study variables included age and gender. Data were analyzed using Cochran’s Q test with the significance level set at a P value less than 0.05.ResultsThe overall frequency of AO was 11.4% for the control group. The frequency of AO in the CGF group was significantly lower than in the non-CGF group (p < 0.001).ConclusionsBased on the results of this study, application of CGF fibrin gel may decrease the risk of AO development after mandibular third molar surgery.Trial registrationThis study was registered in ClinicalTrials.gov database on November 1, 2019 (ID: NCT04151147, retrospectively registered).
Highlights
The aim of this prospective study was to assess the effectiveness of concentrated growth factors (CGF) in preventing the development of alveolar osteitis (AO) after the extraction of partially-erupted mandibular third molars
In 2006 concentrated growth factors (CGF) was developed by Sacco [21]. These products are used to improve the healing process through the release of platelet-derived growth factor (PDGF), transforming growth factors ß-1 (TGF-β1), epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF), which act by stimulating cell proliferation, chemotaxis and angiogenesis [22]
The purpose of this study was to answer the following question: “In cases of individuals who have partially-erupted mandibular third molars removed, is there a lower incidence of AO in those sides treated with CGF than in the opposite sides not treated with CGF?” In our study, we hypothesized that local application of CGF in lower third molar extraction could reduce the rate of AO
Summary
The aim of this prospective study was to assess the effectiveness of concentrated growth factors (CGF) in preventing the development of alveolar osteitis (AO) after the extraction of partially-erupted mandibular third molars. Many attempts have been made to reduce this postoperative complication, which can significantly affect patient’s quality of life in the week following surgery, such as: altered surgical technique (flap designs, different kind of drains) [8,9,10]; systemic antibiotic use; intraalveolar application of medicaments or novel products such as chlorhexidine gel, exogenous retinoic acid, honey, herbal extracts and platelet concentrates [11,12,13,14,15,16,17,18]. Many studies have shown that use of PRP and PRF in tooth extraction stimulates osseous and soft tissue regeneration, and helps to reduce inflammation, pain, and other side effects [16, 17, 23, 24]
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