Abstract
The effect of injection of hypertonic radiopaque solutions on the plasma volume, hematocrit, osmolality, and chloride levels was studied in 8 patients undergoing retrograde aortography and venography. A sudden increase in plasma volume, with a concomitant rise in plasma osmolality and fall in blood hematocrit and plasma chloride concentration, were observed. The changes were ascribed to the passage of cellular water into the plasma in response to a sudden elevation of plasma osmolality, and the passage of interstitial fluid into the plasma in response to changes in acid-base balance. The subsequent decrease in plasma volume, which tended to fall below the control volume, was thought to be due primarily to osmotic diuresis produced by the hyperosmotic radiopaque solution. The relationship of these changes to certain complications of retrograde aortography and angiocardiography are discussed.
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