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Abstract
We investigated the effect of compounds elevating the intracellular cyclic nucleotide levels (cAMP and cGMP) on oocyte maturation induced by dithiothreitol (DTT) in sea cucumber Stichopus japonicus. Forskolin, theophylline, 3-isobutyl-1-methylxanthine and sodium nitroprusside inhibited the DTT-induced oocyte maturation in Stichopus japonicus. The results suggest that, in holothurians, cyclic nucleotides are negative secondary messengers of oocyte maturation, i.e. a decrease in the level of cAMP and cGMP is a necessary condition for the reinitiation of meiosis in the oocytes of these animals.
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