Abstract
Compressed tablets were prepared on a hydraulic press at several different compaction pressures by a standardized technique, using aspirin, dicalcium phosphate dihydrate, calcium phosphato‐carbonate, alumina, and microcrystalline cellulose. All tablets except microcrystalline cellulose contained a cation‐exchange resin as disintegrant. The particle‐size spectra of the disintegrating compacts were evaluated using a particle‐size counter or an air jet sieve. It is shown that compacts made from different materials but of the same initial particle‐size spectra disintegrate to give particles of a considerably different size. Determination of the change in particle size produced by the compaction process provides useful insight into the nature of the compaction process.
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