Abstract
Objective To explore the clinical efficacy of combining early chemotherapy with Zhipu Liujunzi decoction under the concept of strengthening and consolidating body resistance for gastric cancer patients and nursing strategy. Methods The clinical data of 100 patients undergoing radical gastrectomy in our hospital from July 2019 to July 2020 were selected for the retrospective analysis, and the patients were divided into the control group and experimental group according to different treatment methods, with 50 cases in each group. Early chemotherapy after surgery was given to patients in the control group, and on the basis of the aforesaid treatment and under the concept of strengthening and consolidating body resistance, patients in the experimental group took Zhipu Liujunzi decoction and received the nursing strategy, so as to compare their effective rate, adverse reaction rate (ARR), immune function indicators, KPS scores, and nursing satisfaction scores. Results After treatment, the experimental group obtained significantly higher objective remission rate (ORR) and disease control rate (DCR) (P < 0.05), lower carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels (P < 0.001), higher immune parameters levels (P < 0.001), higher KPS scores and lower TCM symptom scores (P < 0.001), lower PSQI scores, SAS scores, and SDS scores (P < 0.001) and higher nursing satisfaction scores (P < 0.001), and lower total accidence rate of toxic side effects (P < 0.05) than the control group. Conclusion Under the concept of strengthening and consolidating body resistance, combining early chemotherapy with Zhipu Liujunzi decoction is a reliable method for improving the immune function and quality of life for gastric cancer patients with higher safety. Such a strategy greatly reduces the tumor marker levels in patients. Further research will be conducive to establishing a better solution for gastric cancer patients.
Highlights
Gastric cancer, a malignant tumor of the digestive tract that occurs in the epithelium of the human gastric mucosa, is currently one of the malignant tumors with the highest morbidity and mortality worldwide
Comparison of Immune Function after Treatment. e immune function of patients was determined by comparing the contents of CD3+, CD4+, and CD8+, and the results showed that the contents of CD3+, CD4+, and CD8+ in patients of the experimental group were significantly higher than those of the control group, which were statistically significant (P < 0.05), see Table 3
With increasing research [17, 18], people have gradually recognized the pathogenesis of gastric cancer, which is associated with multiple factors
Summary
A malignant tumor of the digestive tract that occurs in the epithelium of the human gastric mucosa, is currently one of the malignant tumors with the highest morbidity and mortality worldwide. E concept of “strengthening and consolidating body resistance” holds that the onset of tumor is a systemic disease involving the whole body with Yin-Yang imbalance and excess of pathogenic qi caused by the combination of internal and external factors in the human body; TCM treatment emphasizes removing the pathogenic qi and supporting the vital qi at the same time and believes that reestablishing and restoring the zang-fu viscera function and Yin-Yang balance is the root [8]. E efficacy of this concept in the treatment of sepsis and cervical cancer has been demonstrated, but relevant studies on gastric cancer are currently lacking [10]. The clinical efficacy of combining early chemotherapy and Zhipu Liujunzi decoction under the concept of strengthening and consolidating body resistance and nursing strategy was explored in this study, with the results reported as follows
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