Effect of combined treatment with cryotherapy plus chemo- radiotherapy versus chemo- radiotherapy alone in a non-small-cell lung cancer

Abstract

Background:In end-stage patients when all management options have been used, will oftendevelop compromise of their airways as the cancer continues to progress. Endobronchialtherapy options may help to relieve some of their symptoms, allowing improvement in theirshortness of breath as they go home in combination with other palliative therapies.Objective: To compare the safety; efficacy; and clinical outcome of endobronchialcryotherapycombined with chemotherapy and/ or radiotherapy versus chemo-radiotherapy alone on patientswith Non-small cell lung cancer.Patients and method(s): A prospective randomized clinical trial was carried out on 60 patients,diagnosed as bronchogenic carcinoma non-small cell lung cancer type (NSCLC). The patientsattended the hospital in the chest department, Qena Faculty of Medicine, South ValleyUniversity. Assessment of the patients was done and randomly assigned into twogroups.Group1, Include 30 patients subjected to chemotherapy, radiotherapy andendobronchialcryotherapy.Group2 ,Include include 30 patients subjected to chemotherapy andradiotherapy alone.Result(s): There was significant response meat in symptomatology in Group (1) cryotherapywith regard to cough (P value .000) , dyspnea (P value .000) and haemoptysis (P value .000) .Also, from the functional point of view, in group 1 there were significant improvement tocryotherapy was achieved in FVC(P value .000) , FEV1 (P value .000) , PEFR (P value .000), and 6MWT (P value .000) . However, there were no significant difference in group 2 betweenthe incidence of improvement in FVC , FEV1 , PEFR , and 6MWT.Conclusion:There wasbenifical effect of combination of endobronchialcryotherapy to patientswith lung cancer plus chemo and/ or radiotherapy in the form of improved symptoms and lungfunctions.