Abstract
Objective To study the clinical efficacy of integrated traditional Chinese medicine (TCM) and Western medicine (WM) in treating endometrial cancer and the influence on ultrasound, magnetic resonance imaging (MRI), tumor markers, human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125). Method A total of 152 cases of patients with endometrial carcinoma were randomly divided into two groups: the TCM + WM group and the WM group. The WM group was treated with megestrol acetate tablets, and the TCM + WM group was treated with Radix Astragali injection on the basis of the control group. The levels of inflammatory factors, HE4 and CA125 in serum, were detected using enzyme-linked immunosorbent assay (ELISA) or radioimmunoassay. The characteristics of ultrasound images and MRI images were observed and recorded. Toxicity, side effects, and the 3-year cumulative survival rate after treatment were assessed. Results After treatment, the levels of interleukin-4 (IL-4), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in both groups decreased, and the decrease in the TCM + WM group was more obvious than that in the WM group. There were statistically significant differences between the two groups in lesion shape, boundary, blood flow signal, lesion diameter, resistance index (RI), echo, intima thickness, and muscle layer infiltration from transvaginal ultrasound images after treatment. The diameter, echo, boundary, shape, composition, and enhancement degree of lesions between the two groups have a significant difference. Moreover, the levels of serum HE4 and CA125 in both groups decreased after treatment, and the decrease in the TCM + WM group was more obvious than that in the WM group. There were statistically significant differences between the two groups in the occurrence of myelosuppression, abnormal liver function, decreased platelet number, gastrointestinal reactions, leukopenia, and cardiotoxicity. After three years of follow-up, the cumulative survival rate of the TCM + WM group was 76.32%, and the cumulative survival rate of the WM group was 57.89%. Conclusion Radix Astragali injection combined with megestrol acetate tablets has obvious therapeutic effects against endometrial cancer. Through vaginal ultrasonography and MRI, it can significantly improve the size, shape, and blood flow signals of patients' lesions, reduce the level of serum inflammatory factors and tumor markers HE4 and CA125, reduce the incidence of toxic and side reactions, improve the patient's immunity, improve the patient's condition significantly, and prolong the survival time of patients.
Highlights
Endometrial cancer is a malignant tumor of the female reproductive system, which occurs more frequently during the perimenopausal and postmenopausal periods of women, and the main symptoms are vaginal bleeding and menstrual disorders [1]
Megestrol acetate can act on proliferative cancer cells, binding estrogen receptors, blocking their binding with estrogen, and inhibiting endometrial cancer cell proliferation and metastasis [4]
Studies have found that serum levels of carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4) are closely related to the onset and development of endometrial cancer [12, 13]. is study explores the efficacy of integrated traditional Chinese medicine (TCM) and Western medicine (WM) in endometrial cancer
Summary
Endometrial cancer is a malignant tumor of the female reproductive system, which occurs more frequently during the perimenopausal and postmenopausal periods of women, and the main symptoms are vaginal bleeding and menstrual disorders [1]. Megestrol acetate can act on proliferative cancer cells, binding estrogen receptors, blocking their binding with estrogen, and inhibiting endometrial cancer cell proliferation and metastasis [4] This treatment method can eliminate cancer cells in the patient’s body, it has a cytotoxic effect on normal cells in the proliferation stage, causing adverse clinical symptoms such as leukopenia and myelosuppression in the patient’s body, reducing the patient’s tolerance to treatment, and having high toxic side effects [5]. As an immune enhancer, Radix Astragali injection has been used in the clinical treatment of various diseases (such as ovarian and breast cancer) and has achieved good therapeutic outcomes and antitumor effects [10, 11]. Studies have found that serum levels of CA125 and HE4 are closely related to the onset and development of endometrial cancer [12, 13]. is study explores the efficacy of integrated TCM and WM in endometrial cancer
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