Abstract
Purpose: To study the clinical effects of parenteral edaravone when combined with nimodipine for the treatment of ischemic cerebral injury following cerebral hemorrhage, and its influence on D-dimer, brain natriuretic peptide (BNP) and transcription factor kB (NF-kB) levels. Methods: A total of 102 cases of ischemic cerebral injury after cerebral hemorrhage seen in 215 Hospital of Nuclear Industry in Shanxi, China from January, 2016 to January, 2017 were included in this study. They were randomly divided into two groups, viz, fifty-two cases in control group and fifty cases in observation group. Control group received nimodipine, while the observation group was given edaravone. Before and after treatment, the two groups’ NIHSS scores were compared. Adverse reactions were recorded, and clinical effectiveness was evaluated. Enzyme-linked immunosorbent assay (ELISA) was used to determin thee levels of serum D-dimmer, BNP and NF-kB in the two groups. Results: Before treatment, the two groups’ NIHSS scores did not show significant differences (p > 0.05). However, after treatment, the observation group’s NIHSS score was significantly lower than that of the control group (p 0.05). However, compared with the control group, D-dimmer, BNP and NF-kB levels in the observation group post-treatment decreased significantly (p < 0.05). Conclusion: These results suggest that the combination of parenteral edaravone and nimodipine has relatively high efficiency and safety, mitigates cerebral ischemia and cerebral edema, and controls inflammatory reactions. Thus, its potentials in this regard requires further investigation. Keywords: Edaravone, Nimodipine, Cerebral ischemia, Ischemic cerebral injury
Highlights
Due to increasing aging populations worldwide, cerebral stroke has become the second most important cause of death, and a major factor for disability
In China, cerebral hemorrhage accounts for 10 to 30 % of all Studies have shown that the incidence of ischemic cerebral injury after cerebral hemorrhage is very high, accounting for 13 to 39 % in cerebral hemorrhage patients [2]
The aim of the research was to study the effect of combining edaravone injection with nimodipine on the treatment of patients with ischemic cerebral injury after cerebral hemorrhage, and the effect of this combination on D-dimmer, brain natriuretic peptide (BNP) and NF levels
Summary
Due to increasing aging populations worldwide, cerebral stroke has become the second most important cause of death, and a major factor for disability. Primary cerebral hemorrhage is one of the most deadly strokes. In China, cerebral hemorrhage accounts for 10 to 30 % of all [1]. Studies have shown that the incidence of ischemic cerebral injury after cerebral hemorrhage is very high, accounting for 13 to 39 % in cerebral hemorrhage patients [2]. The mechanism involved in ischemic cerebral injury is still unclear. It has been reported that the incidence of adverse prognosis of ischemic cerebral injury after cerebral hemorrhage within one year increased 6 times [3]. Prevention and treatment of ischemic cerebral injury after cerebral hemorrhage may exert a certain positive effect for improving prognosis of patients
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