Effect of colloidal silicon dioxide and moisture on powder flow properties: Predicting in-process performance using image-based analysis

David Blanco,Osmo Antikainen,Heikki Räikkönen,Jouko Yliruusi,Anne Mari Juppo

doi:10.1016/j.ijpharm.2021.120344

David Blanco, Osmo Antikainen + Show 3 more

Open Access

https://doi.org/10.1016/j.ijpharm.2021.120344

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Abstract

The effect of colloidal silicon dioxide (CSD) on powder flow properties of poor-flowing excipient lactose 200 M was investigated. Binary mixtures of different ratios of CSD as glidant were examined using a modern image-based flow measuring technique. Special attention was placed to subtle variations in powder flow from small changes in glidant concentration (0.025% w/w). Understanding the modes of interaction of particles and their effects on flowability using the method predicted the die filling performance during tablet manufacture. In addition, the importance of moisture content on powder flow properties was empirically underlined. A more efficient range of CSD was detected from 0.10 to 0.50% w/w in most of the tested conditions, which revealed a significant improvement in powder flow performance compared to higher amounts typically handled in the pharmaceutical industry.

Highlights

Poor powder flow is a frequently encountered challenge in phar maceutical drug manufacturing (Tan et al, 2015; Prescott and Barnum, 2000)
During formulation development, the flow of a blend may affect the selection of excipients and it may dictate whether direct compression is used or if some form of granulation is required (Sarfaraz K.Niazi, 2009)
The principles governing direct compression have been well known for many years, the technique has only recently become more popular/attractive as a result of the introduction of certain grades of excipients designed for direct compression (Li et al, 2017)

Summary

Introduction

Poor powder flow is a frequently encountered challenge in phar maceutical drug manufacturing (Tan et al, 2015; Prescott and Barnum, 2000). Direct compression requires fewer processing steps and less equipment (Shanmugam, 2015; Jivraj et al, 2000), which reduces production times and costs. This and other considerations make direct compression the preferred choice and the most economical method for tablet manufacturing in the pharmaceutical industry. The principles governing direct compression have been well known for many years, the technique has only recently become more popular/attractive as a result of the introduction of certain grades of excipients designed for direct compression (Li et al, 2017)

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