Abstract
ABSTRACTThe ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model.Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05).Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge.Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.
Highlights
Bone, in contrast with other tissues, can repair itself without scar formation
Three-dimensional micro-CT reconstructions showed the lack of bone formation inside control defects at 4 and 8 weeks (Figure 1A and J) while some bone formation was observed in defects treated with either collagen sponge (Figure 1B and K) or brin glue (Figure 1C and L) at the same periods
This study was designed to evaluate if treatment with either collagen sponge or brin glue is able to favor bone formation in rat calvarial defects compared with non-treated defects
Summary
In contrast with other tissues, can repair itself without scar formation. Pathological fractures, great bone defects, insuf cient blood supply, bone or surrounding tissues infections, and systemic diseases may negatively in uence bone healing, resulting in delayed unions or nonunions. The common therapeutic approach to treat these clinical situations is the use of bone autografts. Autograft bone is considered the “gold standard” due to the osteoconduction, osteoinduction and osteogenesis promotion as well as angiogenesis without the risk of disease transmission. In oral and maxillofacial surgery, the areas from where autogenous bone can be harvested include extraoral sites as iliac crest, cranial vault and tibia plateau, and intraoral sites as mandibular symphysis, maxillary tuberosity, ramus, tori and exostoses. The use of bone from these areas has some disadvantages, such as limited availability and increased morbidity associated with a second surgical procedure
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