Abstract
Pepsin-solubilized collagen (PSC) from red sea cucumber (Stichopus japanicus) was purified to study the effects on human fibroblast cell line. PSC(1.92g) was purified out of 100g of sea cucumber body. SDS-PAGE analysis of purified PSC indicated that collagen from sea cucumber was α1ß type collagen type I. The PSC did not have cytotoxicity on various cell Iines. The treatment of PSC to human fibroblast cells increase the mRNA of MMP-1 gene not that of MMP-2 compared to untreated control. However, in case of MMP-2, mRNA is decreased upon PSC treatment. Treatment of PSC suppressed the synthesis of collagen in vivo. Unlike to fibroblast, keratinocyte reduced the MMP-2 production upon PSC treatment.
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