Abstract
To test the effect of membrane fixation on ridge volume stability and new bone formation applying guided bone regeneration (GBR). In eight beagle dogs, after bilateral extraction of the maxillary premolars, a box-shaped defect was created on each side. All defect sites were augmented with a particulate bone substitute material, covered with either one of two non-crosslinked collagen membranes (CM1 or CM2) with or without fixation (-F or -UF). Samples were collected after 8 weeks. Histomorphometric and micro-CT analyses were performed. Membrane fixation made no significant difference to the total augmented volume for both membranes (p>0.05). Histological data indicated that at the ridge crest the augmented tissue width amounted to 2.4±0.4 mm in group CM1-F and 2.4±0.5 mm in group CM1-UF, with no significant difference between the groups. Conversely, in CM2-F the augmented tissue width was significantly larger than CM2-UF (2.3±0.1 vs 1.57±0.27, p<0.05). Membrane fixation in contained defects failed to improve ridge volume stability regardless of the membrane type. However, it may enhance the width of augmented ridge at the coronal portion depending on the type of membrane. This article is protected by copyright. All rights reserved.
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