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Abstract
Abstract The effect of low environmental temperature on the response of rabbits to a single injection of human albumin was examined. Animals exposed to cold (4°C ± 2°C) had faster catabolism of antigen and earlier appearance and higher levels of circulating antibody. Mercaptoethanol-resistant antibody was produced early (12 days) in coldexposed animals and late (26 days) in non-exposed animals. The effects of cold exposure on the immune response were as apparent after acute exposure (1 to 2 days) as after chronic exposure (3 to 8 wk).
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