Abstract
Effect Of Coenzyme Q 10 Supplementation On Statin-induced Myalgia, A Randomized Double-blind, Placebo-controlled Study
Highlights
Statins or 3-hydroxy-3-methylglutaryl coenzymeA (HMG-CoA) reductase inhibitors are the most effective medications for reducing low-density lipoprotein cholesterol concentrations, and cardiovascular morbidity and mortality
The present study was designed to evaluate whether Coenzyme Q10 (CoQ10) supplementation would reduce myalgic symptoms in patients with statin-induced myalgia
Myalgia decreased gradually over time in both groups, no difference was noted between the placebo and CoQ10 groups (Fig 1 and table 2)
Summary
A (HMG-CoA) reductase inhibitors are the most effective medications for reducing low-density lipoprotein cholesterol concentrations, and cardiovascular morbidity and mortality. Generally safe, their most serious and frequent side effects are myopathic complaints[1,2]. Statins have been shown to reduce serum levels of CoQ10 16% to 38% 6-11. This fact plus the role of CoQ10 in mitochondrial energy production and the importance of mitochondria in muscle function has prompted the hypothesis that statin-induced CoQ10 deficiency contributes to in statin-associated myopathy. The present study was designed to evaluate whether CoQ10 supplementation would reduce myalgic symptoms in patients with statin-induced myalgia
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