Abstract
Summary Parenteral administration of cobalt to rats stimulated hepatic microsomal heme oxygenase (MHO) activity, depressed cytochrome P-450 content and reduced benzpyrene hydroxylase (BPH) activity, confirming previous reports. By contrast, in the intestinal mucosa, cobalt treatment not only stimulated MHO but in addition increased both cytochrome P-450 and BPH. This differential effect between liver and intestine suggests that the mechanism of the cobalt-mediated stimulation of MHO in the two tissues either differs and/or is unrelated to the turnover of cytochrome P-450.
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