Effect of coagulation function on conditions of patients with community-acquired pneumonia

Abstract

Objective To investigate the effect of coagulation function on assessing conditions of patients with community-acquired pneumonia (CAP). Methods 168 patients with CAP from April 2014 to February 2016 were enrolled for study as observation group, 168 healthy adults were selected as control group according to the matching proportion of 1∶1.According to the pneumonia severity index (PSI), patients in the observation group were divided into high-risk group (n=63) and low-risk group (n=105). Prothrombintime (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fib), platelet (PLT) and D-dimer (DD) were compared among these groups.Simple linear correlation analysis was used to investigate the relationship between these indicators and PSI score.The receiver operation characteristic (ROC) curve was performed to evaluate the predictive value of these indicators and PSI score on death. Results A total of 15 patients (8.9%) died of CAP or complications.PT, APTT, Fib, PLT and DD in observation group were significantly higher than that in control group (P 0.05). ROC curve analysis showed that the AUC of PT, DD, PSI score in predicting prognosis were 0.552 (95%CI0.461-0.646, P>0.05), 0.916 (95%CI0.883-0.956, P<0.01), 0.889 (95%CI0.842-0.931, P<0.01). Conclusions CAP can cause the blood coagulation function disorder.DD is closely related with the severity of CAP, and DD can be used as a predictor of assessing conditions and predicting prognosis of patients with CAP. Key words: Community-acquired pneumonia; Coagulation; D-dimer; Severity