Abstract
Alternative and complimentary usage of the natural compound has raised hopes of finding curative options for liver hepatocarcinogenesis. In the present study, the curative effect of bee honey against diethylnitrosamine (DEN) (50 mg/kg) and carbon tetrachloride (CCl4) (2 mg/Kg)-induced hepatocellular carcinoma (HCC) in male rats in the presence or absence of some chemotherapeutic drugs, Cisplatin (Cis), Cyclophosphamide (CY) and 5- Fluorouracil (5-FU) were investigated. The obtained results demonstrated that treatment with DEN/CCl4 caused oxidative stress as assigned by the increase in malondialdehyde (MDA) and fall in glutathione (GSH) content. Meantime detraction in the antioxidants, including superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST) and glutathione peroxidase (GPx) was observed. Also, the results showed induction of inflammation as reflected by an increase in the levels of both α- fetoprotein and α- fucosidase in the liver. This was accompanied by changes in the hepatic function biomarkers which characterized by the increased levels of transaminases (AST, ALT), alkaline phosphatase (ALP) and γ-Glutamyl transferase (γ-GT) and decrease in total protein content in the serum. In conclusion, the combination of the selected drugs and bee honey may be an effective chemo- preventive and therapeutic strategy for treating DEN and CCl4-induced HCC.
Highlights
The most common types of liver cancer in the world are the hepatocellular carcinoma (HCC)
This study focuses on the role of bee honey in modulating the outgrowth and advancement of hepatocellular carcinoma
No single or combination chemotherapy regimen has been found to be effective in hepatocellular carcinoma, despite the great numbers of forced and passivity studies have been performed with most classes of chemotherapeutic agents [47]
Summary
The most common types of liver cancer in the world are the hepatocellular carcinoma (HCC). It is considered as the second leading cause of cancer related deaths [1]. Especially cirrhosis is considered the vigorous adapting factor for the development of HCC [1]. Carcinogenic compounds such as aflatoxin and N-nitrosamines contaminated food [3] was considered as a risk factor for HCC. It is well known that in early stages of liver cancer, the main therapeutic option is partial hepatectomy. This surgery is proved to be effective and curative but post-surgery, liver cancer recurrence rates remain high, and further improvements in survival will require more effective therapeutic agents that might improve the results of resection [4]
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